A closer look at how machine intelligence is helping doctors see cancer in an entirely new light.
Updated
January 8, 2026 6:33 PM
Serratia marcescens colonies on BTB agar medium. PHOTO: UNSPLASH
Artificial intelligence is beginning to change how scientists understand cancer at the cellular level. In a new collaboration, Bio-Techne Corporation, a global life sciences tools provider, and Nucleai, an AI company specializing in spatial biology for precision medicine, have unveiled data from the SECOMBIT clinical trial that could reshape how doctors predict cancer treatment outcomes. The results, presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting, highlight how AI-powered analysis of tumor environments can reveal which patients are more likely to benefit from specific therapies.
Led in collaboration with Professor Paolo Ascierto of the University of Napoli Federico II and Istituto Nazionale Tumori IRCCS Fondazione Pascale, the study explores how spatial biology — the science of mapping where and how cells interact within tissue — can uncover subtle immune behaviors linked to survival in melanoma patients.
Using Bio-Techne’s COMET platform and a 28-plex multiplex immunofluorescence panel, researchers analyzed 42 pre-treatment biopsies from patients with metastatic melanoma, an advanced stage of skin cancer. Nucleai’s multimodal AI platform integrated these imaging results with pathology and clinical data to trace patterns of immune cell interactions inside tumors.
The findings revealed that therapy sequencing significantly influences immune activity and patient outcomes. Patients who received targeted therapy followed by immunotherapy showed stronger immune activation, marked by higher levels of PD-L1+ CD8 T-cells and ICOS+ CD4 T-cells. Those who began with immunotherapy benefited most when PD-1+ CD8 T-cells engaged closely with PD-L1+ CD4 T-cells along the tumor’s invasive edge. Meanwhile, in patients alternating between targeted and immune treatments, beneficial antigen-presenting cell (APC) and T-cell interactions appeared near tumor margins, whereas macrophage activity in the outer tumor environment pointed to poorer prognosis.
“This study exemplifies how our innovative spatial imaging and analysis workflow can be applied broadly to clinical research to ultimately transform clinical decision-making in immuno-oncology”, said Matt McManus, President of the Diagnostics and Spatial Biology Segment at Bio-Techne.
The collaboration between the two companies underscores how AI and high-plex imaging together can help decode complex biological systems. As Avi Veidman, CEO of Nucleai, explained, “Our multimodal spatial operating system enables integration of high-plex imaging, data and clinical information to identify predictive biomarkers in clinical settings. This collaboration shows how precision medicine products can become more accurate, explainable and differentiated when powered by high-plex spatial proteomics – not limited by low-plex or H&E data alone”.
Dr. Ascierto described the SECOMBIT trial as “a milestone in demonstrating the possible predictive power of spatial biomarkers in patients enrolled in a clinical study”.
The study’s broader message is clear: understanding where immune cells are and how they interact inside a tumor could become just as important as knowing what they are. As AI continues to map these microscopic landscapes, oncology may move closer to genuinely personalized treatment — one patient, and one immune network, at a time.
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Six technology companies showcased solutions for financial research, wealth management, consumer insight and security to investors and institutions.
Updated
November 14, 2026 11:54 PM
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Arnold Lau and King Leung (back row, fourth and fifth from left), Associate Directors-General of Investment Promotion at InvestHK, join the Ventureport team and representatives from the six technology companies. PHOTO: VENTUREPORT
Ventureport hosted the soft launch of InvestHK’s Fast-Track Connect at its AI+ Tech+ Finance+ gathering on 30 October, bringing more than 100 guests to Pier 1929 in Wan Chai.
Sponsored by InvestHK, the event brought investors, institutional representatives and technology companies together to explore investment and business partnerships. Six companies took the stage to showcase software solutions for financial professionals, consumer research, local AI computing and digital asset security.
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The Acting Head of Startups, at InvestHK, Chin-yung (CY), and the Senior Vice President (Fintech), Pauline Fan, introduced Fast-Track Connect. They explained how the agency’s international network connects it with technology companies seeking investment, customers and business opportunities in Hong Kong.
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Their remarks also highlight the need for a more structured approach to build these connections. Investors need easier ways to identify companies that match their interests, while institutions seeking new technology need access to businesses whose products could support their operations or benefit their customers.
To address this need, Fast-Track Connect provides an online platform where technology companies can publish profiles outlining their products and funding needs. Investors and corporate participants can identify relevant businesses and contact them to explore potential investments or collaborations. Service providers and community partners are also part of the platform. Alongside investors and corporate participants, these groups are designated as Champions on the platform.
Curated by InvestHK and supported by the Financial Services and the Treasury Bureau, Fast-Track Connect builds on the Global Fast Track Programme. It aims to help local enterprises expand into Chinese Mainland, Southeast Asia and other markets.
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AlphaPai, an AI-powered investment research platform developed by financial technology company RabyteTech, presented tools for financial research, including gathering data, monitoring financial instruments and comparing information from corporate earnings calls.
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At the event, the team explained how users can give research instructions in everyday language, while the software retrieves and processes information to prepare reports and presentation materials. Examples included tracking market developments and comparing company statements over time. The team also emphasised the importance of traceable sources, allowing analysts to verify the information behind their research.
A2B2.AI, a fintech startup, presented AI- powered tools designed to support investors and wealth advisers. Its specialist AI agents—software designed to carry out particular tasks—help prepare client meeting briefings, monitor financial products approaching maturity and identify market developments relevant to individual clients, according to the team.
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For investors, the tool can help make sense of lengthy documents provided by advisers and bring information from different accounts together to assess risk exposure. For wealth professionals, the tools support preparation and follow-up around client meetings.
The team described its approach as combining AI with human expertise to support financial decision- making. It also clarified that the platform does not execute investment transactions on behalf of clients, leaving those decisions and actions in their hands.
Preferences AI, an AI startup specialising in synthetic consumer research, presented simulated consumer profiles that businesses can use to explore how different audiences might respond to products, pricing and marketing messages. These profiles generate modelled responses rather than feedback from people directly interviewed or surveyed.
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The company described that its profiles are grounded in population data and account for differences between local audiences Businesses can use them to explore pricing or packaging options, as well as ask follow-up questions to understand the reasons behind a particular response. The team also discussed testing its models and working with academics to help validate the approach. It said the technology could help businesses explore consumer preferences more quickly.
ByteFuture, an AI infrastructure startup, focused on running AI on users’ own hardware. It introduced Olares, its operating system, and Olares One, a device designed to run AI models and applications locally.
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Its applications included personal assistance, financial research and content creation. The team argued that users handling private documents or proprietary trading strategies may prefer to retain that material on equipment they control.
A demonstration of AI-generated video illustrated creative work the team said could run locally. It also described applications and agents available through its software marketplace.
PureGlobal, a fintech company, addressed digital asset custody: the systems used to safeguard access to digital assets. Its team described technology for protecting access credentials and supporting offline transactions without a conventional internet connection.
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The presentation focused on infrastructure for institutions holding and transferring digital assets, including security under different operating conditions.
SlowMist, a blockchain security firm, examined the risks of giving AI agents permission to read information and perform tasks. Its examples included malicious instructions concealed in material an agent might encounter and attacks exploiting access granted to software.
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The team discussed security auditing, monitoring and investigations alongside risks arising from third-party tools and an agent’s stored information. One scenario involved exposing a wallet’s recovery phrase, which can give someone control over its assets.