A closer look at how machine intelligence is helping doctors see cancer in an entirely new light.
Updated
January 8, 2026 6:33 PM

Serratia marcescens colonies on BTB agar medium. PHOTO: UNSPLASH
Artificial intelligence is beginning to change how scientists understand cancer at the cellular level. In a new collaboration, Bio-Techne Corporation, a global life sciences tools provider, and Nucleai, an AI company specializing in spatial biology for precision medicine, have unveiled data from the SECOMBIT clinical trial that could reshape how doctors predict cancer treatment outcomes. The results, presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting, highlight how AI-powered analysis of tumor environments can reveal which patients are more likely to benefit from specific therapies.
Led in collaboration with Professor Paolo Ascierto of the University of Napoli Federico II and Istituto Nazionale Tumori IRCCS Fondazione Pascale, the study explores how spatial biology — the science of mapping where and how cells interact within tissue — can uncover subtle immune behaviors linked to survival in melanoma patients.
Using Bio-Techne’s COMET platform and a 28-plex multiplex immunofluorescence panel, researchers analyzed 42 pre-treatment biopsies from patients with metastatic melanoma, an advanced stage of skin cancer. Nucleai’s multimodal AI platform integrated these imaging results with pathology and clinical data to trace patterns of immune cell interactions inside tumors.
The findings revealed that therapy sequencing significantly influences immune activity and patient outcomes. Patients who received targeted therapy followed by immunotherapy showed stronger immune activation, marked by higher levels of PD-L1+ CD8 T-cells and ICOS+ CD4 T-cells. Those who began with immunotherapy benefited most when PD-1+ CD8 T-cells engaged closely with PD-L1+ CD4 T-cells along the tumor’s invasive edge. Meanwhile, in patients alternating between targeted and immune treatments, beneficial antigen-presenting cell (APC) and T-cell interactions appeared near tumor margins, whereas macrophage activity in the outer tumor environment pointed to poorer prognosis.
“This study exemplifies how our innovative spatial imaging and analysis workflow can be applied broadly to clinical research to ultimately transform clinical decision-making in immuno-oncology”, said Matt McManus, President of the Diagnostics and Spatial Biology Segment at Bio-Techne.
The collaboration between the two companies underscores how AI and high-plex imaging together can help decode complex biological systems. As Avi Veidman, CEO of Nucleai, explained, “Our multimodal spatial operating system enables integration of high-plex imaging, data and clinical information to identify predictive biomarkers in clinical settings. This collaboration shows how precision medicine products can become more accurate, explainable and differentiated when powered by high-plex spatial proteomics – not limited by low-plex or H&E data alone”.
Dr. Ascierto described the SECOMBIT trial as “a milestone in demonstrating the possible predictive power of spatial biomarkers in patients enrolled in a clinical study”.
The study’s broader message is clear: understanding where immune cells are and how they interact inside a tumor could become just as important as knowing what they are. As AI continues to map these microscopic landscapes, oncology may move closer to genuinely personalized treatment — one patient, and one immune network, at a time.
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Sonilo and Shutterstock are betting that licensed training data could define the future of AI music.
Updated
May 13, 2026 3:39 PM

A human operating a digital turntable. PHOTO: UNSPLASH
As copyright disputes continue to grow around AI-generated music, Sonilo, the world’s first professionally licensed video-to-music AI platform, has partnered with Shutterstock to train its models on licensed music catalogs.
The agreement gives Sonilo access to Shutterstock’s music library for AI model training. According to the companies, it is Shutterstock’s first partnership with a video-to-music AI platform and the timing is significant. AI music companies are facing growing pressure over how their systems are trained. Artists and record labels have increasingly challenged the use of copyrighted music in AI datasets, especially when licensing agreements or compensation structures are unclear.
That tension has created a divide across the industry. Some companies have continued building models around scraped or disputed data. Others are trying to position licensing as part of the product itself.
Sonilo falls into the second group. The company says its models are trained only on licensed material where artists and rights holders have agreed to participate and receive compensation. The Shutterstock partnership strengthens that position while giving Sonilo access to a larger pool of commercially cleared music.
The collaboration also points to a broader change happening inside generative AI. As AI tools move into commercial production, companies are being pushed to show not just what their models can generate, but also where their training data comes from.
Sonilo’s platform is built around video rather than text prompts. The system analyses footage directly, studies pacing and emotional tone, then generates an original soundtrack to match the content. The company says this removes the need for manual music searches, syncing or editing workflows. The generated tracks are cleared for commercial use across social media, branded content and broadcast production.
Shawn Song, CEO of Sonilo, said: "Music has always been the last unsolved layer of video creation, and video has always carried its own soundtrack. We built Sonilo to hear it and compose from it, without a single text prompt. But how we build matters as much as what we build. While others have chosen to take artists' work without permission and charge creators for the privilege, we've chosen a different path—one where artists are compensated from day one. Partnering with Shutterstock reflects that standard. Every model we train meets a bar the music industry can stand behind, because the most innovative AI platforms don't have to come at the expense of the artists who make all of these possible."
For Shutterstock, the deal expands the company’s growing role in generative AI infrastructure. The company has increasingly focused on licensing content for AI systems across images, video and music.
Jessica April, Vice President of Data Licensing & AI Services at Shutterstock, said: "AI innovation depends on access to high-quality, rights-cleared content and trusted licensing partnerships. Sonilo's approach reflects the growing demand for responsibly sourced training data and commercially safe AI workflows. We're pleased to support companies building generative AI products with licensed content and scalable data solutions that help accelerate innovation while respecting creators and rights holders."
The partnership also comes as Sonilo expands into creator and developer ecosystems. Earlier this month, the company launched as a native node inside ComfyUI, an open-source AI workflow platform used by millions of creators. Sonilo also offers API access for integration into creator tools, video platforms, game engines and other AI systems.
As AI-generated music becomes more common across advertising, creator platforms and digital media, the industry’s focus is shifting beyond generation alone. Questions around licensing, ownership and compensation are increasingly shaping how AI music companies position themselves and build trust with creators.