A closer look at how machine intelligence is helping doctors see cancer in an entirely new light.
Updated
January 8, 2026 6:33 PM
Serratia marcescens colonies on BTB agar medium. PHOTO: UNSPLASH
Artificial intelligence is beginning to change how scientists understand cancer at the cellular level. In a new collaboration, Bio-Techne Corporation, a global life sciences tools provider, and Nucleai, an AI company specializing in spatial biology for precision medicine, have unveiled data from the SECOMBIT clinical trial that could reshape how doctors predict cancer treatment outcomes. The results, presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting, highlight how AI-powered analysis of tumor environments can reveal which patients are more likely to benefit from specific therapies.
Led in collaboration with Professor Paolo Ascierto of the University of Napoli Federico II and Istituto Nazionale Tumori IRCCS Fondazione Pascale, the study explores how spatial biology — the science of mapping where and how cells interact within tissue — can uncover subtle immune behaviors linked to survival in melanoma patients.
Using Bio-Techne’s COMET platform and a 28-plex multiplex immunofluorescence panel, researchers analyzed 42 pre-treatment biopsies from patients with metastatic melanoma, an advanced stage of skin cancer. Nucleai’s multimodal AI platform integrated these imaging results with pathology and clinical data to trace patterns of immune cell interactions inside tumors.
The findings revealed that therapy sequencing significantly influences immune activity and patient outcomes. Patients who received targeted therapy followed by immunotherapy showed stronger immune activation, marked by higher levels of PD-L1+ CD8 T-cells and ICOS+ CD4 T-cells. Those who began with immunotherapy benefited most when PD-1+ CD8 T-cells engaged closely with PD-L1+ CD4 T-cells along the tumor’s invasive edge. Meanwhile, in patients alternating between targeted and immune treatments, beneficial antigen-presenting cell (APC) and T-cell interactions appeared near tumor margins, whereas macrophage activity in the outer tumor environment pointed to poorer prognosis.
“This study exemplifies how our innovative spatial imaging and analysis workflow can be applied broadly to clinical research to ultimately transform clinical decision-making in immuno-oncology”, said Matt McManus, President of the Diagnostics and Spatial Biology Segment at Bio-Techne.
The collaboration between the two companies underscores how AI and high-plex imaging together can help decode complex biological systems. As Avi Veidman, CEO of Nucleai, explained, “Our multimodal spatial operating system enables integration of high-plex imaging, data and clinical information to identify predictive biomarkers in clinical settings. This collaboration shows how precision medicine products can become more accurate, explainable and differentiated when powered by high-plex spatial proteomics – not limited by low-plex or H&E data alone”.
Dr. Ascierto described the SECOMBIT trial as “a milestone in demonstrating the possible predictive power of spatial biomarkers in patients enrolled in a clinical study”.
The study’s broader message is clear: understanding where immune cells are and how they interact inside a tumor could become just as important as knowing what they are. As AI continues to map these microscopic landscapes, oncology may move closer to genuinely personalized treatment — one patient, and one immune network, at a time.
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A wearable ring, conversational AI and US$23M in funding. Sandbar wants to rethink how we interact with technology
Updated
April 1, 2026 8:55 AM
Sandbar's Stream ring. PHOTO: SANDBAR
Sandbar, a New York–based interface startup, has raised US$23 million in Series A funding to develop a wearable device that lets people interact with artificial intelligence via voice rather than screens.
Adjacent and Kindred Ventures led the round; both venture firms focused on early-stage technology startups. The investment brings Sandbar’s total funding to us$36 million. Earlier backing included a US$10 million seed round led by True Ventures, a venture capital firm, as well as a US$3 million pre-seed round supported by Upfront Ventures, a venture firm and Betaworks, a startup studio and investment firm.
Sandbar was founded by Mina Fahmi and Kirak Hong, who previously worked together at CTRL-labs, a neural interface startup acquired by Meta in 2019. Their earlier work explored how computers could respond more directly to human intent — an idea that continues to shape Sandbar’s approach to AI interfaces.
The new funding will help the company expand its team across machine learning, interaction design and software engineering as it prepares to launch its first product. That product, called Stream, combines a wearable ring with a conversational AI interface. The system allows users to speak to an AI assistant without unlocking a phone or opening an app.
The concept is simple. Instead of typing into a screen, users press a button on the ring and talk. The system can capture notes, organize ideas, retrieve information from the web or trigger actions through connected applications.
The ring includes a microphone, a touchpad and subtle haptic feedback. These elements allow the device to respond through gentle vibrations rather than visual alerts. According to the company, the ring only listens when the user presses the button — a design meant to address common concerns around always-on microphones.
That design reflects a larger shift Sandbar believes is underway. As AI assistants become more capable, many startups are experimenting with new ways to interact with them. The focus is moving away from screens and keyboards toward interfaces that feel more natural and immediate.
Stream uses multiple AI models working together to process requests, search the web and structure information in real time. The company says users remain in control of their data and can choose whether to share information with other apps.
Sandbar is also developing a feature called Inner Voice, which responds using a voice customized to the user. The feature will debut during a closed beta planned for this spring, giving the company time to refine how the software behaves in everyday use.
The startup currently employs a team of 15 people. Many have worked on well-known consumer devices including the iPhone, Fitbit, Kindle and Vision Pro. Recent hires include Sam Bowen, formerly of Amazon and Fitbit, who joined as vice president of hardware and Brooke Travis, previously at Equinox, Dior and Gap, who now leads marketing.
Sandbar plans to begin shipping Stream in summer 2026 after completing early testing. As artificial intelligence tools become more integrated into daily life, the company is betting that the next shift in computing will not come from another app — but from new ways for people to interact with AI itself.